The fossil record shows Homo sapiens living in southern and eastern Africa anywhere from 100,000 to 150,000 years ago. Between 50,000 and 60,000 years ago, their expansion out of Africa launched the colonization of the planet by modern humans. By 10,000 BCE, Homo sapiens had spread to all corners of the world. This dispersal of the human species is suggested by linguistic, cultural and genetic evidence.[18][20][21]

After the Sahara became a desert, it did not present a totally impenetrable barrier for travelers between north and south because of the application of animal husbandry towards carrying water, food, and supplies across the desert. Prior to the introduction of the camel,[22] the use of oxen, mule, and horses for desert crossing was common, and trade routes followed chains of oases that were strung across the desert. The trans-saharan trade was in full motion by 500 BCE with Carthage being a major economic force for its establishment.[23][24][25] It is thought that the camel was first brought to Egypt after the Persian Empire conquered Egypt in 525 BCE, although large herds did not become common enough in North Africa for camels to be the pack animal of choice for the trans-saharan trade.[26]