First post: china White by /u/ThreePronger • 2 weeks ago in /d/Opiates Where can i get the best China white, ive been getting from DYKAL for awhile now but his stuff will randomally be a different batch that my nose doesnt agree with! /u/rusty108 2 points 2 weeks ago* What country are you located in? I'm not sure how much you know about heroin and what types of heroin come from where, but let me teach you some heroin geography before I answer your question :) Edit: sorry for the long post. TL;DR: Australian vendors. The 3 main parts of the world where heroin comes from is South East Asia, Afghanistan and Mexico. The USA gets most of its heroin from Afghanistan and Mexico. Europe gets from Afghanistan and SEA, and Australia's heroin primarily comes from SEA. The only place that produces any substantial amount of real China white #4 heroin (not fentanyl) is South East Asia. #4 heroin has been refined 1 step further than #3 heroin and it's converted into a HCL (salt). #4 is always white, very pure when not cut, and highly water soluble in plain cold water. #4 is most suitable for insufflation and intravenous use (snorting and injecting) but can also be smoked. Afghanistan produces #3 heroin. #3 is easier and faster to to produce but the results are a product which is less pure, brown in colour and generally requires heat or ascorbic acid to dissolve as it's a base that's simply been dried out. #3 is most suitable for smoking but can be snorted or injected also. Mexico produces black tar heroin (and #3). Black tar heroin is the most crude and least pure. Black tar is the easiest, cheapest and fastest to produce. Black tar is most suitable for smoking but can be melted down for injection also. South East Asia produces the purest heroin in the world, #4 heroin (China white). Due to proximity, Australia gets most of its heroin from SEA, so to answer your question, if you want real pure #4 heroin, you're looking for anyone selling "double lion stamp heroin" which online you'll only find being sold by Australian vendors, and on the streets mainly SEA and AUS although on the street it'll likely be cut. Double lion stamp is a decades old brand coming from the golden triangle of SEA and it's the primary brand being produced there. It's been around since the days when Khun Sa was in rule and is known to be the purest heroin in the world. The double lion logo has even been featured on bricks of H in some movies. Unfortunately, if you're not in Australia, it will be difficult for you to get double lion stamp heroin as most Australian vendors only ship domestic, but there's no harm in sending them a message to see if they're willing to ship to you, or you can find a trustworthy person in Australia who can receive and redirect the package to you. The USA does get some small amounts of #4 heroin from the odd importation from SEA (although very rare). It's also said that some Columbian syndicates are now producing some #4 but a large majority of "China white" that you'd come across in the US is fentanyl. In fact, I've heard that they're now calling fentanyl powder in the US "China white" which is insane to me because its obviously not heroin at all. You'll know when you have real pure heroin because it'll last over 12 hours and feels completely different. Fentanyl does not last very long and the high feels like a shitty imitation of a heroin high (because it is, it's synthetic so it imitates the effects) and you can feel that's it's missing that little something special that no lab can imitate and only the opium poppies can produce. Hope you've learned something today, and if you already knew all of this, I apologise. I'm sure this info will be useful to someone. /u/socat2me 1 points 2 weeks ago* Yeah man china white just means synthetic H now. SEA #4 is extremely uncommon these days. Sadly there is no more smileawhile. The balance has shifted quite a bit and you don't see as much H coming into the US from the middle east either. Something like 85% of the H trafficked into the US now comes from Mexico, and they've actually stepped up their lab game quite a bit and produce some fairly high purity #4 now along with the much easier to make black tar. The DEA has actually started referring to it as mexican white. Unfortunately most of that get totally stomped all over with synthetics before it makes it to us because most middle men can't resist turning a single brick of actual H into like 5 bricks of synthetic mix, but occasionally you get vendors like mexicanconnection who actually have a connect for uncut #4. Too bad there aren't more vendors like him on the darkweb. I'm sure there are plenty plugs like that out there but I imagine most work exclusively in the streets and it's not as common that they have both the want and the ability to start vending. Especially since it's harder now than it's ever been. OP to answer your question I grabbed some very strong stuff from mexicanbulk when he was on Torrez. I vaporized a loooot of pure fetty and different analogues back in the day (vaporizing is my ROA of choice, don't recommend it because to me it's more addictive than IV since you can just go at it over and over again) and this tasted and felt extremely similar to how I remember original stuff being, with maybe a little cut. The amount of time it would have me out for was about the same too, around 90 minutes or so of like face down on my keyboard snoozing lol. I don't know if he'll be offering it now though, since I know he's on other markets but he seemed to make a point of only offering it on Torrez, he removed his listings of it from markets like Dark0de at one point. /u/rusty108 1 points 2 weeks ago* Look into microdosing naloxone with your heroin. I know it sounds crazy, but I came across a a thread online years ago where a guy had been experimenting with it and I tried it and it seemed to work for me. I did it for a couple of months but got lazy and stopped. It doesn't bring your tolerance down, it's supposed to keep it at the same level so it doesn't increase but I found I also felt my shots slightly more with it. /u/BetterOffDead 1 points 1 week ago So, I got WAY carried away and wrote a super long reply to this. It's 8 pages long, but I think it will be of interest to everyone here who uses opioids. Remember: Save this thread if you like it, otherwise you'll never be able to find it again! First off, I just want to say I come into these forums to help with harm reduction. I'm not an active opioid user anymore, but I try and help out where I can. I also want to say I'm not trying to insult your knowledge, I'm just trying to engage in the Socratic method with you, so please don't take anything I say personally or as me insulting you, or saying you're wrong. The Socratic method: https://en.wikipedia.org/wiki/Socratic_method is a form of cooperative argumentative dialogue between individuals, based on asking and answering questions to stimulate critical thinking and to draw out ideas and underlying presuppositions But, I just wanted to go over a couple different points with you, that I found contrary information for on the web. You might be right, they might be right. We will discuss and decide. :) #4 heroin has been refined 1 step further than #3 heroin and it's converted into a HCL (salt). #4 is always white, very pure when not cut, and highly water soluble in plain cold water. #4 is most suitable for insufflation and intravenous use (snorting and injecting) but can also be smoked. [Note: Spelling errors are all from document] 4.0. SALT FORM DETERMINATION Heroin is most frequently encountered either as the free base or as the hydrochloride salt. It is also not uncommon for the bulk of a heroin sample to be the hydrochloride salt while a few percent is the free base. Two other heroin salt forms, which are encountered less frequently, are the tartrate and the citrate. On rare occasions, a heroin sample will be a combination of the hydrochloride, tartrate, and citrate salts, along with a small quantity of heroin base. To identify the salt forms, each can be separated based on their different solvent solubilities. Once separated through a series of rinses, anion testing can be done where results from selected reactions are determined by the presence or absence of a precipitate. Base: Heroin base is soluble in anhydrous ether; whereas, salts of heroin are completely insoluble. Hydrochloride: Heroin hydrochloride is soluble in chloroform and methylene chloride. Heroin tartrate, heroin citrate, and most inorganic chlorides are insoluble in these solvents. Therefore, dissolve the sample in chloroform or methylene chloride, filter, and then take to dryness. Redissolve the evaporated material in water and treat with silver nitrate solution. A white precipitate will form. After washing the precipitate with water, it should be insoluble in concentrated nitric acid but should be soluble in dilute ammonia solution. From the ammonia solution, it can be reprecipitated by the addition of nitric acid. HEROIN Latest Revision: March 18, 2005 (PDF): https://swgdrug.org/Monographs/HEROIN.pdf So, that didn't say anything about diacetyl morphine being water soluble. But, then I found a contradictory document. Physical form South-west Asian heroin is a brown powder usually in the form of the free base, which is insoluble in water but soluble in organic solvents. The less common south-east Asian heroin is usually a white powder in the form of the hydrate hydrochloride salt (CAS-1502-95-0), which is soluble in water but insoluble in organic solvents. Heroin drug profile: https://www.emcdda.europa.eu/publications/drug-profiles/heroin_en [1/8] /u/socat2me 2 points 1 week ago* This is in response to 1/8 and the basic solubility and chem stuff, if I quoted it this would just get too messy lol. But hey man good on you for researching most people don't take the time to do that. Never just believe what some wackjob on the internet is saying just because it sounds right. I'm just talking about very basic chemistry concepts that are true across the board though (I'm pretty confident my chemistry knowledge is right, I spent a lot of time in college hitting the books and the lab in a very chem heavy major. Lord knows I forgot most of it at this point but this kind of stuff is very basic) Diacetylmorphine isn't not water soluble, Diacetylmorphine is a nitrogenous base, and like most bases it forms a salt when reacted with an acid. The ionic compound formed by the reaction of diacetylmorphine and hydrochloric acid is the very water soluble salt diacetylmorphine hydrochloride. This is just a common chemistry thing, bases are usually hydrophobic/lipophilic and the salts are water soluble because salts are ionic compounds. The polarity of a molecule is what determines it's solubility in a given solvent. Water is a very polar because the electrons are distributed very unevenly within it's internal bonds, it's has a large dipole moment and is thus a polar solvent, the rule of thumb with solvents is like dissolves like, so it dissolves compounds that are very polar. Conversely organic compounds like hexane or ether are very nonpolar, and those are better for dissolving bases. Ethyl acetate is a great solvent for diacetylmorphine base because it's nonpolar but not as much as hexane or ether, and the acetate coordinates well with the acetyl groups on the heroin molecule. Ethyl acetate and hexane mixtures at different ratios are really popular for tuning polarity of stuff like a chromatography column eluent system. In response to 2/8 Mexico definitely grows poppies still. A lot. Check the declassified 2020 National Drug Threat Assessment debriefing. The DEA puts one of these together every year around May. It's basically a report of all their intel, when the next year's report rolls around, the previous one becomes declassified. They have sections on cocaine, heroin, meth, etc. Heroin of Mexican origin accounted for 92 percent of the total weight of heroin analyzed under the HSP, the seventh consecutive year that Mexico has been identified as the primary source of origin for heroin encountered in the United States. and here: The majority of heroin and fentanyl available in the United States is smuggled overland across the SWB. Couriers on commercial airlines transport lesser amounts into the United States. Heroin seizures at the SWB remained high but relatively stable with 2,580 kilograms of heroin seized by CBP in 2019 compared to 2,317 kilograms in 2018. From 2013 to mid-year 2020, the amount of heroin seized at the SWB has increased 39 percent (See Figure 9). CBP reported a combined 1,208 kilograms of fentanyl seized at the SWB in 2019; 1,060 kilograms of fentanyl were seized at POEs and 148 kilograms were seized between POEs by the U.S. Border Patrol. This represents a 62 percent increase in total CBP fentanyl seizures at the SWB And this is unrelated but a comment about average street purity, and where they also mention the mexican white (#4) According to HDMP data for 2019, the average purities for heroin at the retail (street) level varied by type, with Mexican white powder and Mexican black tar heroin (the most prevalent types of heroin available at the retail level) averaging 47 percent and 45 percent purity, respectively. Although the presence of both fentanyl and various FRCs were observed in retail-level heroin exhibits analyzed under the HDMP, fentanyl remained the leading synthetic compound detected in a majority of these heroin exhibits. /u/BetterOffDead 1 points 1 week ago Just as a little aside, I thought I would tell you guys a funny story. Back in the late 70s the DEA wrote a field guide for their agents on heroin. Unfortunately, in the entire document they describe exactly how to grow it, harvest it, and convert it to heroin. So, their "guide" for their agents actually became one of the best guides around for how to actually make good heroin. Here's the file in doc file if you want to check it out Opium - Poppy Cultivation, Morphine and Heroin Manufacture (DOC File): https://anonfiles.com/Jd7aNbXbv6/Opium_-_Poppy_Cultivation_Morphine_and_Heroin_Manufacture_doc So, I assume you want want something like the base if you were planning on smoking it, and if it was combined with HCl you could take it IV, plug it, or take it orally. Increase Oral Potency of Drugs /post/3741d122396fd5431296 >#4 is most suitable for insufflation and intravenous use (snorting and injecting) but can also be smoked. Wouldn't the base be better for smoking? Because powder cocaine is basically cocaine HCl is the version you snort and IV, but when you cook it into crack you're removing the HCl off it to make it cocaine base, and that's why it can be smoked. So, I would assume this would be the same for heroin, is it not? Mexico produces black tar heroin (and #3). Black tar heroin is the most crude and least pure. Black tar is the easiest, cheapest and fastest to produce. Black tar is most suitable for smoking but can be melted down for injection also. From my understanding, most of the Mexican cartels have entirely given up on growing poppies. Because it takes an entire season to make one batch of heroin, and you have to cultivate and grow it and so forth, but they can make fentanyl 24/7 because it's just a bunch of chemicals they're getting from China and blending it up. Inside the Sinaloa Cartel’s Fentanyl Smuggling Operations: https://www.youtube.com/watch?v=N8PRske_j80 The market is just better for it, and there's no demand except for a few holdouts who miss heroin in favor of fentanyl. But it's cheaper to produce, can be produced 24/7 365, whereas poppies only sprout... I don't even know how any times a season, but then they have to cut it, let the opium juice run out, collect it, and then convert that to heroin. Plus they can sell fentanyl for much more money since it's so much more potent. Mexico produces black tar heroin (and #3). Black tar heroin is the most crude and least pure. Black tar is the easiest, cheapest and fastest to produce. Black tar is most suitable for smoking but can be melted down for injection also. Maybe Mexico still produces black tar, I could be wrong. It's obviously coming from somewhere. That just reminds me of that HBO documentary I watched in the early 2000s called Black Tar Heroin: The Dark End of the Street, which I have courteously found for you (it took quite awhile to find) and it is on Vimeo: https://vimeo.com/299797585. It's a very sad and depressing watch. Don't watch it if you're in a bad place or bad mood. Due to proximity, Australia gets most of its heroin from SEA, so to answer your question, if you want real pure #4 heroin, you're looking for anyone selling "double lion stamp heroin" which online you'll only find being sold by Australian vendors, and on the streets mainly SEA and AUS although on the street it'll likely be cut. Double lion stamp is a decades old brand coming from the golden triangle of SEA and it's the primary brand being produced there. I mean, SURELY some people are counterfeiting the logo of this stuff. There's no watermark in the world that's unable to be counterfeited. [2/8] /u/BetterOffDead 1 points 1 week ago In fact, I've heard that they're now calling fentanyl powder in the US "China white" which is insane to me because its obviously not heroin at all. That's what I've heard my whole life. China White = fentanyl, no natural ingredients found in it. Fentanyl does not last very long and the high feels like a shitty imitation of a heroin high (because it is, it's synthetic so it imitates the effects) and you can feel that's it's missing that little something special that no lab can imitate and only the opium poppies can produce. Sometimes beggars can't be choosers. But, it depends on the fentanyl you're using. There are SO many varieties and salts and isomers and derivatives of fentanyl, that some could be hitting the all the receptors, and some hitting only a few or one of those receptor sites. But, you want to try find that are mainly mu receptor agonists, as that will provide the most analgesic and euphoric effects compared to the other opiate receptors. Incidentally, while searching I came across a very interesting study on opiate receptors in the brain and a few key ways you can trigger them to possibly enhance your high. [This is your KEY to this study - it often references MOR, KOR, DOR, NOR, & ZOR.] To date, five types of opioid receptors have been discovered-mu receptor (MOR), kappa receptor (KOR), delta receptor (DOR), nociception receptor (NOR) and zeta receptor (ZOR). Within these different types are a subset of subtypes, mu1, mu2, mu3, kappa1, kappa2, kappa3, delta1, and delta2.] The utilization of opioids in clinical pharmacology started after the extraction of morphine from the opium poppy Papaver somniferum in 1806 with its use further intensified after the discovery of hypodermic needles in 1853. Opioids divide into two types, those being endogenous and exogenous. Some endogenous opioids that bind to the receptors are enkephalins, endorphins, endomorphins, dynorphins, and nociception/orphanin. Exogenous opioids like morphine, heroin, and fentanyl are substances that are introduced into the body and bind to the same receptors as the endogenous opioids. The different types of opioid receptors bind to their respective agonist counterparts. See Table 1-1 Mu1,2,3 receptors (MOR) bind to endogenous ligands - beta-endorphin, endomorphin 1 and 2 with proopiomelanocortin (POMC) being the precursor. The mu-1 receptor is responsible for analgesia and dependence. The mu-2 receptor is vital for euphoria, dependence, respiratory depression, miosis, decreased digestive tract motility/constipation. Mu-3 receptor causes vasodilation. Kappa receptors (KOR) bind to dynorphin A and B (Prodynorphin as the precursor). They provide analgesia, diuresis, and dysphoria. Delta receptors (DOR) bind to enkephalins (precursor being Proenkephalin). They play a role in analgesia and reduction in gastric motility. Nociceptin receptors (NOR) bind to nociceptin/orphanin FQ (Pre-pronociceptin is the precursor) causing analgesia and hyperalgesia (depending on the concentration). Zeta receptors (ZOR) regulate developmental events in a variety of normal and tumorigenic tissues and cells. See this handy chart for more information: https://ibb.co/d55whxw [3/8] /u/BetterOffDead 1 points 1 week ago Function Analgesia The nervous system comprises a high concentration of opioid receptors in periaqueductal gray, locus ceruleus (LC), rostral ventral medulla, substantia gelatinosa of the dorsal horn of the spinal cord and the peripheral afferent nerves. The peripheral receptors sense painful stimuli, and impulses get carried to the dorsal horn of the spinal cord for relay to higher centers of the brain. MOR activation by an opioid agonist in the midbrain causes the formation of descending inhibitory impulses(mediated through inhibition of GABA interneurons) to the periaqueductal gray which stimulates descending inhibitory neurons that trigger enkephalin-containing neurons connected directly with the dorsal horn, subsequently leading to decrease in nociceptive transmission from the periphery to the thalamus. (See Fig 4.) Exogenously administered opioids cause analgesia both through direct inhibition of substantia gelatinosa of the dorsal horn and through peripheral afferent nerves. Stress MOR play a central role in toning down the central stress response through inhibition of secretion of norepinephrine (NE) from locus ceruleus (LC), attenuating the stressful state characterized by sustained release of NE under the effect of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVH). (See Fig 5.) Therefore, MORs are instrumental in recovering from stress, demonstrated by the reduction in the risk of developing post-traumatic stress disorder (PTSD) based on evidence obtained from studies showing the beneficial effect of morphine administration after a stressful event.[1] Mood and Reward Presence of high density of MOR in the limbic system (emotional center) regulates mood and rendering these receptors potential targets to treat mood disorders like anxiety and depression. The reward center of the brain comprising of ventral tegmental area (VTA) that sends projections to the ventral striatum within the mesolimbic dopamine system. MOR stimulation, through its inhibition of GABA secretion, results in the release of dopamine. Dopamine is responsible for the rewarding effects produced by opioid administration, leading to positive reinforcement. Issues of Concern The different types of opioid receptors bind to their respective agonist counterparts. See Table 1-1 Mu1,2,3 receptors (MOR) bind to endogenous ligands - beta-endorphin, endomorphin 1 and 2 with proopiomelanocortin (POMC) being the precursor. The mu-1 receptor is responsible for analgesia and dependence. The mu-2 receptor is vital for euphoria, dependence, respiratory depression, miosis, decreased digestive tract motility/constipation Mu-3 receptor causes vasodilation. Kappa receptors (KOR) bind to dynorphin A and B (Prodynorphin as the precursor). They provide analgesia, diuresis, and dysphoria. Delta receptors (DOR) bind to enkephalins (precursor being Proenkephalin). They play a role in analgesia and reduction in gastric motility. Nociceptin receptors (NOR) bind to nociceptin/orphanin FQ (Pre-pronociceptin is the precursor) causing analgesia and hyperalgesia (depending on the concentration). Zeta receptors (ZOR) regulate developmental events in a variety of normal and tumorigenic tissues and cells. So, ideally you want your opioid of choice to focus on your mu receptors (MOR) and act as an agonist at that location. You'll notice Above, that most all of the other Opiate Receptors have some effect on analgesia, finding drugs that mainly hit those Mu receptors is what you ideally want. CB1 Receptor Some recent studies have shown the interaction of MORs with Cannabinoid (CB1) receptors; this has been observed through increased potency of opioids like morphine when co-administered with CB1 receptor agonist 9-Tetrahydrocannabinol (THC). Another point of evidence is the significant modulation of the ERK pathway on stimulation of MOR/CB1R heterodimer, compared to the modulation observed with individual receptor stimulation. So, it appears cannabanodiol and THC can enhance the effects of opioids. Further down below in this post I'll a couple more dietary supplements that can help improve or lengthen or your opioid high. So, now would be a perfect time to stock up on some full spectrum CBD Oil from TheCBDistillery (Note: You'll get a coupon code for at least 20% off your order if you use that link, but you may have to open it in an in private/incognito window in a clearnet browser as adblockers, etc can block it from popping up) One of the highest rated CBD vendors out of Denver. Known for their slabs of crystal CBD isolate and great prices. The CBDistillery https://tinyurl.com/TheCBDistillery-HQ-CBD is one of the most popular CBD manufacturers today! For good reason, their products are some of the cheapest and highest quality on the market. They have a very large variety of products, constantly releasing new flavors that are high quality, and even sell terpenes extracted from their hemp. They grow everything themselves in Colorado. Each batch is tested for quality and purity and you can look up on their website your batch number and see how it tested at. I would recommend the 2500mg CBD Oil with the 0.03% THC (unless you have access to legal weed in your state, or you just don't like the feeling of THC with your opioid high, this will just hit those receptors slightly). It's about $130 a bottle, so I wouldn't blame you for going for the 500mg full spectrum for $30. [4/8] /u/BetterOffDead 1 points 1 week ago Studies have shown that interactions exist between MOR and alpha-2A adrenergic receptors altering the functional activity of these individual receptors. A significant interaction of MOR with the neurokinin-1 receptor (NK1) leads to changes in the internalization and resensitization processes. Lucky for you, you can buy an alpha a2a receptor antagonist OTC legally. The problem? It can be highly stimulatory. The compound is called Yohimbine HCL. Warnings: Yohimbine can cause extreme anxiety in individuals predisposed to anxiety. Yohimbine may trigger manic psychosis or suicidal episodes in people with bipolar disorder Yohimbine can interact with a large amount of neurological medications and should not be used in conjunction with these medication without consultation with a doctor Yohimbe is highly stimulatory There is a high chance of yohimbine interacting with neurological medication Many supplements containing yohimbine either do not list its dose, or its dose is inaccurate by up to 150%. The actual dose of yohimbine in many supplements has been found to vary from the labeled dose from 25-150% Having said that, you will be dealing with is EXTREMELY low for a starter dose so you can try it and see if it's for you. Unfortunately, you can't buy sample packs of 1 or 2 pills, you have to buy the whole bottle and just see if it works. The dose we're starting off at is 2.5mg, which is a VERY low dose and shouldn't even phase you (unless you haven't eaten anything in awhile, are taking it before bed, have bipolar disorder, or have an extremely severe case of anxiety. I have anxiety, and I can handle 2.5mg of yohimbine just fine.) Because I'm reading this study as I'm writing this post, I'm learning all this stuff for the most part too. So, after you've tried 2.5mg for a few days, you can bump it up to 5mg, and 7.5mg, and so on as you feel comfortable with it. Will this make you higher or keep you higher for longer? I don't know, I've never tried it. But Yohimbine is definitely an alpha a2a receptor antagonist and according to the study, taking a compound that activates this receptor site "leads to changes in the internalization and resensitization processes". So to me, resensitization can indicate that your opiate receptors might become more sensitive to the presence of the current opioid level you take or if you take slightly more. This is PrimaForce 2.5mg Yohimbine HCl Tested for Purity & Potency: https://a1-supplements.com/primaforce-yohimbine-hci so you will be in hand with a good brand. You'll also have to open that link in a clearnet browser in order to purchase it. It's only $10 for 90 caps and you get 20% off with the coupon code GIFT20 (at the time of writing). Below I'll mention a few other supplements you can take to try and enhance your opioid high, these will also be needed to be opened in a clearweb browser, unfortunately. Since 99% of all websites use JavaScript on the internet, it's just a fact of life. Read More about Yohimbine on Examine.com: https://examine.com/supplements/yohimbine/ [5/8] /u/BetterOffDead 1 points 1 week ago* I was looking over some of the side effects, and I noticed this: Endocrine Abnormalities Stimulation of opioid receptors located in the hypothalamus inhibits GnRH release, which results in reduced estrogen and testosterone secretion. Hence, chronic activation of these receptors leads to osteoporosis and sexual dysfunction, presenting as decreased libido, infertility, and increased bone fragility.[11] These receptors in the hypothalamus cause reduced the activity of the hypothalamic-pituitary-adrenal axis, resulting in low levels of ACTH and cortisol. Low cortisol levels present clinically with nonspecific symptoms- anorexia, nausea, vomiting, abdominal pain, weakness, fatigue, lethargy, and fever. So, when you're using opioids, you're decreasing all your sex hormones as well as growth hormone. In men, obviously decreased estrogen isn't all that big of an issue, as testosterone is the main source of libido and sexual activity. However, if you are a woman, increased bone fragility can be a concern. If you're a woman using opioids between the age range of mid thirties or plus, I might consider taking a supplement with Ipriflavone. This Klaire Labs Osteothera Plus Ipriflavone Tablets Ipriflavone with Calcium, Vitamin D, and magnesium should do the trick. It's a little bit pricey, but it's a lot less pricey and pain inducing than breaking an ankle or hip or sosmething. Ipriflavone acts as sort of a synthetic estrogen that helps keep calcium in the bones. It would help a great deal as a preventative measure.: https://amzn.to/3E9yiYO Here's the supplement facts: https://ibb.co/d2HGy04 Now for guys, if you're losing your testosterone, estrogen and GH levels, that's going to give you a skinnier look probably as you have less of an appetite (obviously) and have trouble developing musculature. There's nothing you can do about your GH levels, despite all those products on TV advertising GH boosting - those are all bullshit. Unless you wanna start talking about injecting peptides, and assuming you're on heroin or fentanyl or whatever, you probably don't care too much about that anyway. But, in terms of libido enhancement you could start with some 4-andro. 4-Andro is a direct precursor to testosterone. It's a bit pricey, but depending on how often you want to have sex with your partner, it can be too pricey. This is sort of the 'herbal' version of that formula, it's called Testojack 250 and it tons of ingredients that can boost libido and help you stay erect. NOW TestoJack 200: https://a1-supplements.com/now-testojack-200 Ingredients: https://ibb.co/M2q8M5p It has very standardized blends of ingredients that actually boost testosterone through various means which I won't go into directly here because it will take forever. But, it has Horny Goat Weed, 250mg of Tribulus which has been used by decades by bodybuilders looking to increase their testosterone, Maca and Ginsing for energy, so all and all it's a good blend. Now, if you have $70 to spare, I would tell you to buy Hi-Tech Pharmaceuticals Sustanon 250, named after the famous anabolic steroid bodybuilders love which has: 4 androstene-3b-ol,17-one Propionate 4 androstene-3b-ol,17-one Enanthate 4 androstene-3b-ol,17-one Isocaproate 4 androstene-3b-ol,17-one Decanoate 3 Beta-hydroxy-5alpha-androstan-17-one aka Epiandrosterone (brief summary of it - you can ignore 99% of those side effect warnings because, presumably you won't be taking it daily) That's 4 different kinds of 4 Andro bound to different short, medium, and long lasting esters that help it to release over time, increasing your testosterone levels and increasing your sex drive like crazy. *** Hi-Tech Sustanon 250 https://samedaysupps.co/sustanon-250-by-hi-tech-pharmaceuticals-42-tablets.html Now, if you need some Cialis or Viagra, you can obviously also find that on DNMs, although I can point you to a source I personally use. The price is pretty decent and it's on a clearweb site. And again, with those links I've posted you have to open them in a clearweb browser. You can take Sustanon 250 and Testojack together. Anyway, moving on. [6/8] /u/BetterOffDead 1 points 1 week ago* I dug through the rest of the study looking for anything that might boost your opioid high or reduce tolerance, but that's stuff is way beyond me and there isn't I'm aware of you can take to reduce tolerance. Armaan Dhaliwal; Mohit Gupta. Physiology, Opioid Receptor Treasure Island (FL): StatPearls Publishing; 2021 Jan-.: https://www.ncbi.nlm.nih.gov/books/NBK546642/ Last but not least, supplements that can improve your opioid high or increase it's length. 1) DLPA aka DL-Phenylalanine. It's a racemic mixture of 50% L-Phenylalanine and 50% D-Phenylalanine. Both of these have significant chemical properties in your body, but the D-Phenylalanine is the most important we're looking at for opioid enhancement. DL-Phenylalanine is a mixture of D-phenylalanine and L-phenylalanine. The reputed analgesic activity of DL-phenylalanine may be explained by the possible blockage by D-phenylalanine of enkephalin [An enkephalin is a pentapeptide involved in regulating nociception in the body. The enkephalins are termed endogenous ligands, as they are internally derived and bind to the body's opioid receptors.] degradation by the enzyme carboxypeptidase A.[15][16] The mechanism of DL-phenylalanine's supposed antidepressant activity may be accounted for by the precursor role of L-phenylalanine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain levels of norepinephrine and dopamine are thought to have an antidepressant effect. D-Phenylalanine is absorbed from the small intestine and transported to the liver via the portal circulation. A small amount of D-phenylalanine appears to be converted to L-phenylalanine. D-Phenylalanine is distributed to the various tissues of the body via the systemic circulation. It appears to cross the blood–brain barrier less efficiently than L-phenylalanine, and so a small amount of an ingested dose of D-phenylalanine is excreted in the urine without penetrating the central nervous system.[17] So, you can buy DLPA online for relatively cheaply but you'll probably need a couple grams of it to have a noticable effect. You can buy bulk DLPA as a powder, but I have no idea what it tastes like, and you will probably also need an electric whisker: https://amzn.to/328ZNUZ (otherwise it's just going to turn into a clumpy mess) which you can get on Amazon for about $15 to get it fully blended. I have never tasted plain DLPA powder, but my suspicion is that it tastes awful. :) Do you'd want to mix it with some kind of juice or Koolaid or something to mask the taste and just chug it down. Bulk DLPA Powder: https://amzn.to/3GRqIUo For those not so brave souls, you can buy some pretty cheap good quality DLPA 500mg 100 caps for $12: https://amzn.to/3J0txnZ You can also buy D-Phenylalanine 500mg 60 caps for $17, but that Doctor's Best is the only company I've ever seen selling it alone: https://amzn.to/3yFfmQD if you just wanted to play with it's potential endorphin boosting/keeping from breaking down abilities, but again - you will still need a few grams. So, if it was me, I would buy the bulk powder, an electric whisker, and mix like 2-5g in some OJ or something, blend it up, and down it like a shot. Here is the full text on a study you can puruse at your leisure if you so wish, DL-Phenylalanine Markedly Potentiates Opiate Analgesia – An Example of Nutrient-Pharmaceutical Up-Regulation of The Endogenous Analgesia System (PDF): https://anonfiles.com/lb05j7cew9/DL-phenylalanine_markedly_potentiates_opiate_analgesia_an_example_of_nutrient-pharmaceutical_up-regulation_of_the_endogenous_analgesia_system_pdf [7/8] /u/BetterOffDead 1 points 1 week ago* 2) Agmatine: https://a1-supplements.com/nutrakey-agmatine-powder This has shown GREAT potential in increasing the effects of opioids, but against, it's going to take multiple grams. The one I linked is $20 for a 30 day supply if you took 1g/day. But, it's also been micronized (which means the particles have been ground up ultra fine, so it won't irritate your stomach or anything), so you will probably still need that electric whisker and I'm sure it's gonna taste bad, but I would go for 3-5g/day. If you just want to try capsules, you can get good quality SNS Agmatine 500mg 90/caps for $20: https://a1-supplements.com/sns-agmatine-xt "Preliminary research suggests agmatine has potential use in the treatment of neuropathic pain and drug addiction. It also protects the brain from toxins and strokes. Though supplementing agmatine by itself can decrease the perception of pain, it works synergistically with painkillers like morphine and fentanyl. Agmatine’s synergy with opioids allows it to reduce pain killer tolerance, the possibility of addiction, and pain itself. [...] 3.8 Opioidergic Neurotransmission The activation of imidazoline receptors (specifically I2 receptors) in the adrenal glands appears to induce the release of β-endorphin (a naturally produced opioidergic pain killer)[93] which has central and peripheral implications. Enhancement of opioidergic analgesia[124] and the attenuation of tolerance development[142] have been noted with NMDA antagonists before (possible role of Agmatine) although one study has noted that the prevention of tolerance was reliant on activation of imidazoline receptors.[143] Agmatine is able to release some opioids inherently by activating imidazoline receptors in the adrenal glands. So in regards to the following information of how agmatine interacts with opioids (which should apply to β-endorphin as well), it is somewhat synergistic with itself in persons with functioning adrenals The acute analgesic (pain killing) effects of morphine are augmented when coadministered with agmatine,[144] which is mediated by α2A receptors[145] and appears to extend to oxycodone[146] and fentanyl (two other opioidergic drugs similar to morphine). For acute analgesia, agmatine appears to be synergistic with opioids Agmatine has been found to potently inhibit tolerance to μ-opioid agonists (Endo-2 and DAMGO-AG) with intrathecal injections of 4nmol[113] which appears to be effective for up to 48 hours following a single dose.[113] This has also been noted in rhesus monkeys given oral agmatine (40-80mg/kg).[147]" Source: Examine.com - https://examine.com/supplements/agmatine/research/#neurology_opioidergic-neurotransmission Again, I apologize, but all the links I posted will require a clearnet browser to open them in and work and buy them. If you're in tails and have Signal you can save them as links to "Notes to Myself" and when you boot out of tails, you can open up Signal on the PC and access it, save it to a secure notepad, put it on bitbin.com or whatever you choose. Let me know what you think or if you have any comments, questions, suggestions or critiques. Thanks, B.o.D. [8/8]