Isaac Stat Qty Health 3 Damage 3.5(*1) Tears 1 Shot Speed 1 Range 23.75 Speed 1 Luck 0 Starting Items One regular bomb. The D6 (once unlocked) On Use: Any Treasure Room item will be rerolled into a different item. (Defeat enemy Isaac in the Cathedral using ??? to unlock this item.) Starting Effects None How to Unlock Default Character Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Isaac's Head Defeat Satan Mom's Knife Defeat Isaac Isaac's Tears Defeat The Chest D20 Defeat the Dark Room Missing Poster Defeat Mom's Heart/ It Lives on Hard Lost Baby Defeat Ultra Greed Lil' Chest Defeat Hush Fart Baby . Defeat Mega Satan Cry Baby . Defeat Everything on Hard Buddy Baby Biblical Reference Child whom God asked his father Abraham to sacrifice. Magdalene Stat Qty Health 4 Damage 3.5(*1) Tears 1 Shot Speed 1 Range 23.75 Speed 0.85 Luck 1 Starting Items Yum Heart On Use: Heals one Red Heart. Recharge: Four rooms. Starting Effects None How to Unlock Have 7 or more Red Heart containers at one time. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Isaac The Relic Defeat Boss Rush Maggy's Bow Defeat Satan Guardian Angel Defeat The Chest Celtic Cross Defeat the Dark Room Maggy's Faith Defeat Mom's Heart/ It Lives on Hard Cute Baby Defeat Ultra Greed Censer . Defeat Hush Purity . Defeat Mega Satan Red Baby . Defeat Everything on Hard Colorful Baby Biblical Reference Mary Magdalene, a prostitue before meeting and befriending Jesus. Cain Stat Qty Health 2 Damage 3.5(*1.2) Tears 1 Shot Speed 1 Range 17.75 Speed 1.3 Luck 0 Starting Items One regular key. Starting Effects Lucky Foot Passive: Increases Luck How to Unlock Have 55 or more pennies at once. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Isaac Sack of Pennies Defeat Boss Rush Cain's Other Eye Defeat Satan Bomb Bag Defeat The Chest Cain's Eye Defeat the Dark Room Abel Defeat Mom's Heart/ It Lives on Hard Glass Baby Defeat Ultra Greed Evil Eye . Defeat Hush D12 . Defeat Mega Satan Green Baby . Defeat Everything on Hard Picky Baby Biblical Reference Son of Adam and Eve. Commited the first act of murder when he killed his brother Abel. Judas Stat Qty Health 1 Damage 3.5(*1.35) Tears 1 Shot Speed 1 Range 23.75 Speed 1 Luck 0 Starting Items Three pennies. Book of Belial On Use: Increases damage dealt for the current room. Recharge: Three rooms Starting Effects None How to Unlock Defeat Satan. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Judas' Shadow Defeat Satan Judas' Tongue Defeat Isaac Guillotine Defeat the Chest The Left Hand Defeat the Dark Room Curved Horn Defeat Mom's Heart/ It Lives on Hard Shadow Baby Defeat Ultra Greed My Shadow . Defeat Hush Betrayal . Defeat Mega Satan Brown Baby . Defeat Everything on Hard Belial Baby Biblical Reference One of the 12 disciples. Betrayed Jesus in exchange for money. Eve Stat Qty Health 2 Damage 3.5(*0.75) Tears 1 Shot Speed 1 Range 23.75 Speed 1.23 Luck 0 Starting Items None Starting Effects Dead Bird Passive: When hit, a dead bird spawns and attacks enemies in the current room. W'hore of Babylon Passive: When at one heart of life, damage and speed is increased. How to Unlock Do not pick up any Hearts (Red, Spirit, Eternal, Demon) for two floors. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Eve's Mascara Defeat Satan Razor Blade Defeat Isaac Eve's Bird Foot Defeat The Chest Sacrificial Dagger Defeat the Dark Room Black Lipstick Defeat Mom's Heart/ It Lives on Hard Crow Baby . Defeat Ultra Greed Black Feather . Defeat Hush Athame . Defeat Mega Satan Lil' Baby . Defeat Everything on Hard ♥♥♥♥♥ Baby Biblical Reference First woman. Took a bite from the forbidden fruit, comitting the first act of sin. Samson Stat Qty Health 3 Damage 3.5(*1) Tears 0.95 Shot Speed 1.31 Range 18.75 Speed 1.1 Luck 0 Starting Items None Starting Effects Bloody Lust Passive: Each time damage is taken, damage dealt is increased a small amount. Damage bonus resets each floor. How to Unlock Do not take damage for two floors. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Samson's Chains Defeat Satan Blood Rights Defeat Isaac Bloody Lust Defeat The Chest Bloody Penny Defeat the Dark Room Samson's Lock Defeat Mom's Heart/ It Lives on Hard Fighting Baby . Defeat Ultra Greed Lusty Blood . Defeat Hush Blind Rage . Defeat Mega Satan Rage Baby . Defeat Everything on Hard Revenge Baby Biblical Reference Born by God to defeat the Philistines. After revealing his secret, lost his power and was subsequently captured and blinded. Azazel Stat Qty Health -1 Damage 3.5(*1.5) Tears -14 Shot Speed 1 Range 17.75 Speed 1.25 Luck 0 Starting Items 0 - The Fool On Use: Teleports user to starting room on current floor. Starting Effects Special Starts with three Demon Hearts as health. When a Demon Heart disappears, damage is dealt to all enemies in the room. Azazel can still obtain Red Heart Containers normally. Special Instead of tears, charges up and fires a short-range Brimstone beam that resembles a thick laser. Flying Can fly over rocks, holes, and poop. Ignores damage from floor spikes and pools of hazardous liquid. Can still be damaged by bombs, red poop, enemies, and projectiles. How to Unlock Make three deals with the Devil in one run. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush The Nail Defeat Satan Daemon's Tail Defeat Isaac The Satanic Bible Defeat The Chest Abaddon Defeat the Dark Room Demon Baby Defeat Mom's Heart/ It Lives on Hard Wrapped Baby Defeat Ultra Greed Unlocks Lilith Defeat Hush Maw of the Void . Defeat Mega Satan Black Baby . Defeat Everything on Hard Sucky Baby Biblical Reference A scapegoat, or in some translations, the name of a fallen angel who helped further the corruption of Man preceeding the great flood. Lazarus Stat Qty Health 3 Damage 3.5(*1) Tears 1 Shot Speed 1 Range 17.75 Speed 1 Luck -1 Starting Items A random pill. Starting Effects Special Upon death, will revive once with one Red Heart container and the Anemic passive. Anemic (after revive) Passive:Range up. Passive: When damage is taken, leave a trail of blood that damages enemies. Resets when leaving current room. How to Unlock Have four Spirit Hearts at once. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Missing No. Defeat Satan Broken Ankh Defeat Isaac Lazarus' Rags Defeat the Dark Room Pandora's Box Defeat the Chest Store Credit Defeat Mom's Heart/ It Lives on Hard Begotten Baby Defeat Ultra Greed Key Bum Defeat Hush Empty Vessel Defeat Mega Satan Long Baby Defeat Everything on Hard Dripping Baby Biblical Reference Was ressurected by Jesus four days after dying. Eden Stat Qty Health ? Damage ? Tears ? Shot Speed ? Range ? Speed ? Luck ? Eden is neither male nor female. Using Eden requires the use of a special token. Additional tokens are obtained each time Mom's Heart / It Lives is defeated. Starting Items Randomized, see below Starting Effects Special Starts with... Randomized Stats Random hair style 1: coin, bomb, key, pill, or card 0-1: activated item 0-2: passive items How to Unlock Defeat The Womb chapter. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Undefined Defeat Satan The Book of Secrets Defeat Isaac A Blank Card Defeat The Chest Mysterious Paper Defeat the Dark Room Mystery Sack Defeat Mom's Heart/ It Lives on Hard Glitch Baby Defeat Ultra Greed GB Bug . Defeat Hush Eden's Blessing . Defeat Mega Satan Yellow Baby . Defeat Everything on Hard Cracked Baby Biblical Reference None directly, although it's interesting to note that the place Adam and Eve orignally resided was the Garden of Eden. ??? Stat Qty Health -1 Damage 3.5(*1.05) Tears 1 Shot Speed 1 Range 23.75 Speed 1.1 Luck 0 Also known as the Blue Baby. Starting Items The Poop On Use: Spawns a poop. Recharge: One room. Starting Effects Special Starts with three Soul Hearts. Cannot obtain Red Heart Containers. Any time health would be increased, ??? instead gains that many Soul Hearts. How to Unlock Defeat Mom's Heart ten times. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush ???'s Only Friend Defeat The Chest Fate Defeat Satan Forget Me Now Defeat Isaac D6 Defeat the Dark Room ???'s Soul Defeat Mom's Heart/ It Lives on Hard Dead Baby . Defeat Ultra Greed Cracked Dice . Defeat Hush Fate's Reward . Defeat Mega Satan Blue Baby . Defeat Everything on Hard Hive Baby Biblical Reference None. Often thought to refer to Edmund McMillen, original game creator, and some of his past work which depict a similar character. The Lost Stat Qty Health 0 Damage 3.5(*1) Tears 1 Shot Speed 1 Range 23.75 Speed 1 Luck 0 Dies if game is left mid-run. Starting Items One penny. Starting Effects Flying Can fly over rocks, holes, and poop. Ignores damage from floor spikes and pools of hazardous liquid. Can still be damaged by bombs, red poop, enemies, and projectiles. Special Cannot pick up Hearts of any kind and cannot have health increased. Damage taken results in a death. Revive items function normally. Note that as a side effect, all Devil Room items can be taken without cost. How to Unlock You must die as specific characters and by specific means. These four can be done in any order (in one play session) as long as there are NO other losses in between. Currently, seeds will work. The following order is recommended: As Isaac, die by a Mulliboom's explosion in either the Basement or Cellar (Seed: JTMD EZPF, go down). As Magdalene, die by your own bomb in either the Caves or Catacombs. As Judas, die by Mom. Easiest way is to damage self to half a heart before entering then running to middle of room. As Azazel, die by Satan during his second phase (after The Fallen, before the hooves) in Sheol. Mulliboom: Appears rarely. Slightly more common in Cellar. Setting difficulty to Hard adds a few more rooms with Mullibooms to the generation list, making them a bit more common to encounter. You can use your own bombs to blow up doors to get through rooms with lots of enemies without killing them, saving some time. Unlike other explosions, these deal only a half heart of damage. Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush D100 Defeat Satan The Mind Defeat Isaac Isaac's Heart Defeat The Chest The Body Defeat the Dark Room The Soul Defeat Everything on Hard Godhead Defeat Mom's Heart/ It Lives on Hard -0- Baby . Defeat Ultra Greed Zodiac . Defeat Hush Sworn Protector . Defeat Mega Satan White Baby Biblical Reference None directly. A lost soul, resembles the spirit that leaves the body of other characters upon death. Lilith Stat Qty Health 1 Damage 3.5(*1) Tears 0 Shot Speed 1 Range 23.75 Speed 1 Luck 0 Starting Items Box of Friends On Use: Duplicate's Isaac's familiars for the duration of the current room. Recharge: Two rooms Starting Effects Special Lilith is blindfolded and cannot fire tears. Incubus Passive: Summons a familiar that fires tears. Gains the same effects as Isaac's tears. Special Starts with two Demon Hearts as health. When a Demon Heart disappears, damage is dealt to all enemies in the room. Lilith can still obtain Red Heart Containers normally. How to Unlock Beat Greed Mode with Azazel Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Immaculate Conception Defeat Satan Serpent's Kiss Defeat Isaac Rune Bag Defeat The Chest Cambion conception Defeat the Dark Room Succubus Defeat Mom's Heart/ It Lives on Hard Goat Head Baby Defeat Ultra Greed Box of Friends Defeat Hush Incubus Defeat Mega Satan Big Baby . Defeat Everything on Hard Dark Baby Biblical Reference In some texts, Lilith was Adam's first wife but was cast out of the Garden of Eden when she refused to listen to God, who later replaced her with Eve. Lilith is often referenced with demonic associations in bibical texts. Keeper . Stat Qty Health -1 Damage 3.5(*1.2) Tears 1 Shot Speed 1 Range 23.75 Speed 0.85 Luck -2 Starting Items One regular bomb. One coin (after defeating the Hush with Keeper). Wooden Nickel On Use: 50% chance to drop a coin. Recharge: One room (Unlocked by defeating Isaac in the Cathedral) Store Key Trinket: May open shops without using a key. (Unlocked by defeating Satan in Sheol) Starting Effects Special Starts with two "coins" of health. Being damaged loses a health. Picking up a coin gains a health. Cannot exceed two health. HP Up items and effects will refresh Keeper's health to two. Special Heart pickups turn into Blue Flies. Special Triple Shot - shoots three tears per shot. How to Unlock Donate 1000 coins to the Greed Mode donation machine (causing it to explode). Related Achievements These achievements are gained when you complete an area with this character, unlocking an item. --- Action Unlocked Defeat Boss Rush Sticky Nickel . Defeat Satan Store Key . Defeat Isaac Wooden Nickel . Defeat The Chest Deep Pockets . Defeat the Dark Room Karma . Defeat Mom's Heart/ It Lives on Hard Super Greed Baby . Defeat Ultra Greed Rib of Greed . Defeat Hush Keeper's Penny . Defeat Mega Satan Noose Baby . Defeat Everything on Hard Sale Baby Biblical Reference n/a