Slow brain function Slowed pulse and breathing Lowered blood pressure Poor concentration Confusion Fatigue2 Dizziness Slurred speech Fever Sluggishness Visual disturbances Dilated pupils Disorientation, lack of coordination Depression Difficulty or inability to urinate Addiction Higher doses can cause impairment of memory, judgment and coordination, irritability, paranoia,3 and suicidal thoughts. Some people experience the opposite of the intended effect, such as agitation or aggression. Using sedatives (drugs used to calm or soothe) and tranquilizers with other substances, particularly alcohol, can slow breathing and the heart rate and even lead to death.