There are 98/97 secrets in the Binding of Isaac. Here's a list of them, categorized. Progression Secrets Secrets you will unlock as you keep playing. A Radioactive Spider: Complete the Basement. Spelunker: Complete the Caves. The Womb: Complete the Depths. Something from the Future: Complete the Basement 25 times. Something Cute: Complete the Caves 20 times. Something Sticky: Complete the Depths 30 times. Something Icky!: Complete the Womb / Utero 15 times. Task Based Secrets Secrets you will unlock upon completing specific tasks. Mr. Mega: Destroy 10 tinted rocks, in total. A Small Rock: Destroy 50 tinted rocks, in total. The Bean: Destroy 50 piles of poop, in total. Gamekid: Visit 10 Arcades. Mom's Pill Bottle: Use a Blood Bank 20 times. The Necronomicon: Use the XIII Death tarot card 4 times. Mom's Eye: Collect Mom's Eye and either her Heels, Lipstick, Pad or Bra in one run. The Common Cold: Collect either two of the following, in one run: Growth Hormones, Roid Rages, Virus. The Parasite: Collect two of either of the following, in one run: Bob's Rotten Head, Dead Cat, Tammy's Head. A Bandage: Defeat Famine, War, Pestilence and Death in one run, obtaining 4 Cubes. Guppy's Hairball: Obtain three of the following items, and transform into Guppy: Dead Cat, Guppy's Head, Guppy's Tail, Guppy's Paw. The Pinking Shears: Die 100 times. A Lump of Coal!?: Defeat Krampus. A Halo:: Defeat Mom by using the Bible. The Book of Sin: Defeat all the standard minibosses, over multiple playthroughs. The Left Hand: Defeat Ultra Pride. Characters and Character's Items Secrets relating to characters or their items Magdalene: Obtain 7 or more heart containers in one run. Yum Heart: See: Magdalene. Cain: Obtain 55 or more pennies in one run. The Lucky Foot: See: Cain. Eve: Make two Deals with the Devil in one run. A Curse: See: Eve. A Dead Bird: See: Eve. Judas: Beat Mom's Heart for the first time. The Book of Belial: See: Judas. Samson: Skip on two Treasure Items and kill Mom. ???: Beat Mom's Heart (It Lives) for the 10th time. The Poop: See: ???. The D6: Beat Mom's Heart (It Lives) with ???. Special Bosses and Related Items Secrets related to unlockable bosses and their item drops. The Harbingers: Defeat Mom once. A Cube of Meat: See: The Harbingers. The Book of Revelations: Defeat any of the four Horsemen of the Apocalypse, once. Little Steve: Defeat Steven. Little C.H.A.D.: Defeat C.H.A.D. Little Gish: Defeat Gish. Womb Completion Secrets Secrets unlocked upon defeating the final boss in the Womb. Note: Some are under Characters and Character's Items. A Noose: Defeat the final boss in the Womb for the second time. The Nail: Defeat the final boss in the Womb for the third time. A Quarter: Defeat the final boss in the Womb for the fourth time. A Fetus in a Jar: Defeat the final boss in the Womb for the fifth time. Everything is Terrible!!!: Defeat the final boss in the Womb for the sixth time. The Wafer: Defeat the final boss in the Womb for the seventh time. Money=Power: Defeat the final boss in the Womb for the eighth time. It Lives!: Defeat the final boss in the Womb for the ninth time. A Cross: Defeat the final boss in the Womb with Maggy. A Bag of Pennies: Defeat the final boss in the Womb with Cain. A Robo-Baby!: Defeat the final boss in the Womb with Judas. The Razor: Defeat the final boss in the Womb as Eve. Blood Lust: Defeat the final boss in the Womb as Samson. Sheol Completion Secrets Secrets unlocked upon defeating the final boss in Sheol. Mom's Knife: Defeat the final boss in Sheol with Isaac. Guardian Angel: Defeat the final boss in Sheol with Maggy. The Monster Manual: Defeat the final boss in Sheol with Judas. Blood Rights: Defeat the final boss in Sheol with Samson. A Demon Baby: Defeat the final boss in Sheol with Eve. A Bag of Bombs: Defeat the final boss in Sheol with Cain. A Forget Me Now: Defeat the final boss in Sheol with ???. Cathedral Completion Secrets Secrets unlocked upon defeating the final boss in the Cathedral. The Polaroid: Defeat the final boss of the Cathedral six times in total The D20: Defeat the final boss of the Cathedral with Isaac. The Crucifix: Defeat the final boss of the Cathedral with Maggy. Curved Horn: Defeat the final boss of the Cathedral with Judas. Bloody Penny: Defeat the final boss of the Cathedral with Samson. Sacrificial Knife: Defeat the final boss of the Cathedral with Eve. Abel: Defeat the final boss of the Cathedral with Cain. Rainbow Baby: Defeat the final boss of the Cathedral with ???. Chest Completion Secrets Secrets unlocked upon defeating the final boss of the game, in the Chest. Maggy's Faith: Defeat the final boss with Maggy. Judas' Tongue: Defeat the final boss with Judas. Samson's Lock: Defeat the final boss with Samson. ???'s Soul: Defeat the final boss with Eve. Cain's Eye: Defeat the final boss with Cain. Eve's Bird Foot: Defeat the final boss with ???. Challenge Secrets Secrets unlocked by completing the challenges. The Candle: Complete Challenge 1. Lucky Toe!: Complete Challenge 2. Burnt Penny: Complete Challenge 3. Guppy's Tail: Complete Challenge 4. A Fish Head: Complete Challenge 5. Mega Fetus: Complete Challenge 6. Super Fan: Complete Challenge 7. Spider Butt: Complete Challenge 8. Counterfeit coin: Complete Challenge 9. The Egg Sack: Complete Challenge 10. No Damage Secrets Secrets unlocked by taking no damage on their respective floors. Note: Every floor can be replaced with their alternate, ex: Basement, Cellar. Basement Boy: Complete the Basement I and II without taking any damage. Spelunker Boy: Complete the Caves I and II without taking any damage. Dark Boy: Complete the Depths I and II without taking any damage. Mama's Boy: Complete the Womb I and II without taking any damage. Final Secrets You must also pick up all the items atleast once. Golden God: Unlock all the vanilla game achievements / secrets and items. Platinum God: Unlock all the achievements / secrets and items. See the Achievements section for explanation.