On November 14, 2013, Naughty Dog discharged a teaser trailer for another Uncharted amusement, saying that it will be discharged for the PlayStation 4. The trailer included voice over by Todd Stashwick, who was to play Sam, Nathan Drake's more established sibling, in the amusement. The trailer demonstrates an old guide of the African landmass while the voice over can be listened. The guide stops at Madagascar and Île Sainte-Marie is stamped, which was a piece of Francis Drake's travel course. A Latin sentence is composed alongside the drawing of a skull: Hodie mecum eris in paradiso (which means "Today shalt thou be with me in heaven"), a quote from the Book of Luke 23:43. 

In March 2014, it was reported that Amy Hennig, the arrangement essayist and innovative executive, and Justin Richmond, the amusement chief of Uncharted 3: Drake's Deception and Uncharted 4: A Thief's End at the time, had both left the studio, joining Visceral Games and Riot Games, individually. In April 2014, Todd Stashwick, who voiced the storyteller in the teaser trailer and was set to play Sam in the diversion, was declared to never again be included in the amusement, with the part being recast. 

In June 2014, Naughty Dog co-president Evan Wells uncovered that amusement executives for The Last of Us, Neil Druckmann and Bruce Straley, were currently driving the undertaking in Hennig's nonattendance. Accordingly, huge numbers of the story components and eight months of shooting were scrapped and abandoned.[ At the Sony E3 2014 public interview in June 2014, the title of the amusement was uncovered to be Uncharted 4: A Thief's End alongside a 2015 discharge window.On December 6, 2014, a gameplay demo of Uncharted 4 was appeared as the underlying presentation of the PlayStation Experience. Troy Baker later affirmed by means of Twitter that he had voiced Drake's more established sibling Sam, who showed up in the demo inverse Nathan Drake. Albeit a few faultfinders attested that the diversion endured a graphical downsize when contrasting the demo with the E3 2014 teaser trailer, Naughty Dog clarified that the craftsmanship bearing was distinctive in the demo, which brought about a changing look in visuals. 

On June 16, 2015, another demo was showcased toward the end of Sony's E3 Press Conference. The demo included a much greater environment, a lot of annihilation, new battle moves, and the arrival of Nathan Drake's tutor, Victor Sullivan. An augmented trailer at an E3 press instructions likewise uncovered the arrival of Nathan's significant other Elena Fisher. On July 8, 2015, it was reported that Robin Atkin Downes would be included in the amusement. While Naughty Dog initially focused on a rate of 60 casings for every second for the entire amusement, it was reported that a 30 outlines for each useless is presently being focused for the crusade, while 60 outlines for every second is as yet being focused for the multiplayer modes. Underhanded Dog beforehand communicated challenges in getting the amusement to achieve 60 outlines for each second, yet sooner or later clarified that they'd drop the thought on the off chance that it traded off the player's experience of playing the diversion. Amid The Game Awards 2015, another character, Nadine Ross (voiced and movement caught by Laura Bailey), was uncovered. 

While the multiplayer was constrained to a determination of 900p, the battle stays at a local 1080p. At PlayStation Experience 2015, it was uncovered that the diversion will include player controlled exchange choices, a first in the arrangement. 

By March 18, 2016, improvement of Uncharted 4 halted as the amusement was submitted for assembling.