For 100 years, Reader's Digest has shared some of the world's best wit and wisdom on the art of living. To mark Reader's Digest's 100th anniversary in 2022, we searched our archives and collected 100+ quotes that we think will continue to stand the test of time. The dates in parentheses represent when they were first published in the magazine. For more quotations for every occasion, check out our other compilations, which include funny quotes, life-changing quotes, uplifting quotes, and life is short quotes, Best quotes about life 1. "Not in doing what you like, but in liking what you do is the secret of happiness." —J.M. Barrie (August 1933) 2. "My father gave me the best advice of my life. He said, 'Whatever you do, don't wake up at 65 years old and think about what you should have done with your life.'" —George Clooney (July 2006) 3. "Make it a rule of life never to regret and never to look back. Regret is an appalling waste of energy; you can't build on it; it's only good for wallowing." —Katherine Mansfield (April 1941) 4. "I'd rather regret the risks that didn't work out than the chances I didn't take at all." —Simone Biles (July/August 2020) 5. "If your ship doesn't come in, swim out to it! "—Jonathan Winters (June 1990) 6. "A pessimist is one who makes difficulties out of his opportunities; an optimist is one who makes opportunities out of his difficulties." —Robert Mansell (August 1933) continue reading... msn.com/en-us/lifestyle/smart-living/111-of-the-most-powerful-quotes-about-life/ar-AAPQAYn Continue reading