The number of things that can cause the extinction of humans are not only numerous, but happen with some frequency relative to the history of complex species on our planet. Things like ice age, massive world suffocating volcanic explosions, continental shifts, tsunamis, locusts, Jersey Shore, etc. Add to the daunting number of "natural disasters" native to our rather touchy ball of dirt all of the many threats from space, from solar flares to a stray gamma burst to an asteroid that comes out of nowhere.