Blaze was born and grew up in Cavaillon, Vaucluse. He went to Paris to study law, but also to learn music, at the Conservatoire de Paris. After having passed several more years in Vaucluse (southeastern France), Castil-Blaze moved back to Paris.
A large part of his activities consisted of adapting French and foreign opera for different stages in French provinces. In these cases, Castil-Blaze adapted the libretto as well as the music. This arranging work was highly criticized, but Castil-Blaze claimed that this permitted part of the public to become familiar with opera.