I've made some money with Clixsense, a little bit with my clicks and referral clicks, but I've made more by advertising affiliate links there. To be honest, with advertising affiliate links, the conversion rates have been really low. With that being said, you'd probably be better off advertising your opt-in page there, then marketing to your list. People are on clixsense to click ad's and make a fraction of a cent, they have no relationship with you yet. Whereas people that opt-in to your list are already familiar with you, and want information from you. Your conversion rates will be much, much higher with them.