My long-term research focus has been in clinical pharmacokinetics drug disposition and pharmacodynamics drug action , particularly as these disciplines relate to: women's health; effects of gender, age, and other pathophysiologic states on pharmacokinetics and pharmacodynamics; and novel approaches to therapeutic drug monitoring. More recent interests include pharmacogenetics and pharmaceutical outcomes evaluations. Every day I use my clinical practice experiences to identify relevant pharmacokinetic and pharmacodynamic problems that are then studied through my laboratory-based research program. As an integrator who bridges the gap between the basic and clinical sciences, my goal for my research program is to address these clinical problems from a qualitative, quantitative, and mechanistic perspective and to make a difference in the health and well-being of patients i. Publications Prevention and Treatment of Hyponatremia in Patients with Subarachnoid Hemorrhage: A Systematic Review. Ng, Marianna Leung, Alissa J. Kiang and Mary H. Ensom DOI: 2016 Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs DOI: 2016 A Qualitative Review on the Pharmacokinetics of Antibiotics in Saliva: Implications on Clinical Pharmacokinetic Monitoring in Humans Tony K. Mabasa, Ivy Chow, Mary H. Kiang, Kyle John Wilby, Mary H. Ensom, Andrew Steer, Colin T. White, Eddie Kwan, Roxane R. Bottorff JL, Haines-Saah R, Kelly MT, Oliffe JL, Torchalla I, Poole N, Greaves L, Robinson CA, Ensom MH, Okoli CT, Phillips JC DOI: PubMed: 2014 Applying the Principles of Disease Screening to the Prostate Cancer Debate UBC Pharmaceutical Sciences Student Journal 2014 Clinical Pharmacokinetic Drug Interactions Associated with Artemisinin Derivatives and HIV-Antivirals Tony K. Kiang, Karen Ng, Mary H. T Sherwin, Tony K. T Sherwin, Michael G. Craig Phillips, John L. Ensom DOI: 2012 Therapeutic Drug Monitoring in Interstitial Fluid: A Feasibility Study Using a Comprehensive Panel of Drugs Tony K. Kiang, Veronika Schmitt, Mary H. Ensom, Beverly Chua, Urs O. Häfeli DOI: 2012 Pharmacokinetics of Antimalarials in PregnancyA Systematic Review Kyle J. Erin Schwenger, Jane Dumontet, Mary H. Okoli, Milan Khara, Iris Torchalla, Mary H. Kiang, Boris Stoeber, Beverly A. L Ting, Marie-Odile Benoit-Biancamano, Olivier Bernard, K. Wayne Riggs, Chantal Guillemette, Mary H. Jennifer E Isenor, Mary H. The Canadian journal of hospital pharmacy Ensom MHH 2010 Research and Scholarship for Researcher-Educator Faculty: Top 10 Survival Tips. Ting, Nilufar Partovi, Robert D. A Critical Review Penny Bring, Mary H H Ensom DOI: 2008 Will Genetic Testing for Warfarin Dosing Ever be Ready for Prime Time? Soon JA, Meckley LM, Levine M, Marciante KD, Fielding DW, Ensom MH PubMed: 2007 A Systematic Review of Limited Sampling Strategies for Platinum Agents Used in Cancer Chemotherapy Gabriel W Loh, Lillian S L Ting, Mary H H Ensom DOI: 2007 Efavirenz and Nevirapine in HIV-1 InfectionIs There a Role for Clinical Pharmacokinetic Monitoring? Karen Dahri, Mary H H Ensom DOI: 2007 Is C2 Monitoring or Another Limited Sampling Strategy Superior to C0 Monitoring in Improving Clinical Outcomes in Adult Liver Transplant Recipients? L Ting, Nilufar Partovi, Robert D Levy, K. Wayne Riggs, Mary H. Ting, Eric Villeneuve, Mary H. Strong, Amanda Lai, Dennis Primmett, Colin T. Morrison Hurley, Mumtaz Virji, Mary H. Magee, Saman Miremadi, Jing Li, Carol Cheng, Mary H. Soon, Marc Levine, Brenda L. Julie Cates Scott, Nilufar Partovi, Mary H. Ensom, Gina Chong, Danyi Zhou, Bev Beaudin, Stephen Shalansky, Tony R. Ensom, Nilufar Partovi, Diane Decarie, Randall J. Dumont, Guy Fradet, Robert D. Soon, Marc Levine, Mary H. Marc Levine, Mary H. Chang, Payal Patel DOI: 2001 Comment: publication rates of abstracts. Dumont and Mary H. Ensom DOI: 2000 Vancomycin Overdose in a 6-Month Old Female DOI: 2000 Stability of Aminophylline in Extemporaneously Compounded Oral Suspensions Journal of Informed Pharmacotherapy 2000 Allergies. A Motherhood IssueNon-Refereed Pharmacy Practice 2000 Low-Molecular-Weight Heparins in Pregnancy Mary H. Dennis Clifton, Mary H. H Ensom, George A. Ensom DOI: 1998 Alpha1-acid glycoprotein concentrations and cerebrospinal fluid drug distribution after subarachnoid hemorrhage. Woodward DK, Hatton J, Ensom MH, Young B, Dempsey R, Clifton GD PubMed: 1998 Candles Under Bushels: Unpublished Abstracts Canadian Journal of Hospital Pharmacy 1998 From Abstract to Publication: What Helps Make the Grade? McCoy RA, Clifton GD, Booth DC, Bartels LA, Chandler MH PubMed: 1997 Premenstrual asthma: the effect of estrogen on symptoms, pulmonary function, and beta 2-receptors. Chandler MH, Schuldheisz S, Phillips BA, Muse KN PubMed: 1997 Integrating Pharmacokinetics into Point-of-Care Information Systems W. Greg Leader, Stanley L. Greg Leader, Mary H. Tsubaki T, Chandler MH PubMed: 1994 Effects of long-term oral carvedilol on the steady-state pharmacokinetics of oral digoxin in patients with mild to moderate hypertension. Wermeling DP, Field CJ, Smith DA, Chandler MH, Clifton GD, Boyle DA PubMed: 1994 Development of a Clinical Pharmacology Graduate Program at the University of Kentucky American Journal of Pharmaceutical Education 1994 Clinical Pharmacokinetics Services in the United States Chinese Pharmaceutical Journal 1994 Modified Michaelis-Menten equation for estimating unbound-phenytoin concentrations. Greg Leader, William H. Buffington, Victor Lampasona, Mary H. Dennis Clifton, John T. Hamelin BA, Blouin RA, Wolf KM, Clifton GD, Chandler MH PubMed: 1992 Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin. Dennis Clifton, Nausherwan K. Toler SM, Wilkerson MA, Porter WH, Smith AJ, Chandler MH DOI: PubMed: 1990 Home monitoring of theophylline levels: a novel therapeutic approach. Chandler MH, Clifton GD, Louis BA, Coons SJ, Foster TS, Phillips BA PubMed: 1990 Effect of fluorescein concentration on gentamicin immunoassay results. Huang Chandler, Robert J. Pharmacogenetics of Mycophenolate in Thoracic Transplant Recipients: Role of UDP-Glucuronosyltransferases This study seeks to determine if the inter-patient variability observed in the mycophenolate pharmacokinetics of thoracic transplant recipients can be partially explained by genetic variability in the UDP-glucuronosyltransferase UGT enzymes responsible for its metabolism. Pharmacokinetics and Pharmacodynamics of Intravenous Immunoglobulin IVIG Prior to and During Pregnancy in Patients with Unexplained Secondary Recurrent Spontaneous Abortion RSA This is the first study ever to evaluate the pharmacokinetics study of what the body does to a drug and pharmacodynamics study of what drugs do to a body prior to and during pregnancy in patients of intravenous immunoglobulin with recurrent pregnancy loss. Distinguished Service Award, B. Branch Canadian Society of Hospital Pharmacists C. It can take years to turn scientific breakthrough into new interventions and treatments. Funding helps speed the pace of change.