Human history becomes more and more a race between education and catastrophe. H. G. Wells
With the rise of the industrial nations in the late 19th and early 20th centuries, respect for nature was relinquished, and human control and domination of nature and her resources began.
Over the time frame of less than one and a half centuries, Gaia's health had declined dramatically to a point where all species on the planet began to suffer health issues to a point that epidemics could not be stemmed with medicines, or even poisons, all treatments of the symptoms reacted just as if more damage was being applied.
In the face of government corpotocracy, a small portion of humanity began to awaken to the devastating effects the dominant civilization had on the planets and began to form small pockets of resistance to the powers that be and their minions.