Zlatan Ibrahimovic can cope with Milan's quick turnaround in matches but Rossoneri head coach Stefano Pioli is unsure how long his side will be without fellow key player Hakan Calhanoglu.
Veteran striker Ibrahimovic scored twice in Saturday's 2-1 win over bitter rivals Inter and is part of Milan's 22-man squad for Thursday's Europa League Group H opener with Celtic in Glasgow.
Pioli has resisted the urge to rest his big hitters and insists they can cope with the demands of a packed fixture list, with four more matches to come in the space of 10 days.
"Zlatan is fine and so are his team-mates," Pioli told Sky Sport Italia. "I think the team is fine, because it's more the head that commands the legs.
"The derby has taken away a lot of mental energy more than physical, as always happens in this period.
"We will have a block of three weeks where we will play seven times and they will be close and very competitive matches, but I will certainly field the best side on Thursday."
Calhanoglu will play no part at Celtic Park, however, after spraining his ankle in the narrow win over Inter last weekend as Milan stretched their winning run to nine matches.
He has thrived post-lockdown, scoring and assisting a combined 15 goals in Serie A since June - a tally matched by Ibrahimovic and bettered only by Cristiano Ronaldo (16) and Francesco Caputo (17).