Short-term effects
Loss of appetite
Increased heart rate, blood pressure, body temperature
Dilation of pupils
Disturbed sleep patterns
Nausea
Bizarre, erratic, sometimes violent behavior
Hallucinations, hyperexcitability, irritability
Panic and psychosis
Convulsions, seizures and death from high doses
Long-term effects
Permanent damage to blood vessels of heart and brain, high blood pressure leading to heart attacks, strokes and death
Liver, kidney and lung damage
Destruction of tissues in nose if sniffed
Respiratory (breathing) problems if smoked
Infectious diseases and abscesses if injected
Malnutrition, weight loss
Disorientation, apathy, confused exhaustion
Strong psychological dependence
Psychosis
Depression