Once again, Italian researchers have given us the gift of discovery of two new phytocannabinoids; cannabidihexol (CBDH) and Δ9-tetrahydrocannabihexol (THCH).
CBDH and THCH have the same structure as their more famous counterparts, with the only difference being in the length of the alkyl chain; CBD/THC have a 5-term while CBDH/THCH have a 6-term alkyl chain.
They were found in the FM2 cultivar, synthesized in the laboratory and compared to their respective monomethyl ether derivatives.
The isolated CBDH was also evaluated for its pharmacological activity in mice, where 1,2 mg/kg (i.p.) significantly reduced the late phase of the formalin-induced nocifensive behavior and 2 mg/kg had a significant antinociceptive effect, compared to the vehicle group. Interestingly higher doses (3/5 mg/kg) didn’t have these effects.
The concentrations of CBDH (27 μg/g) found in the FM2 were were too low to exert pharmacological effects.
After Δ9-THCB, CBDB, Δ9-THCP, and CBDP, THCH and CBDH join the ever expanding family of phytocannabinoids. I'm excited at the prospect of the therapeutic potential of all of these compounds, for various medical conditions, in various combinations. So much to research!
Link https://lnkd.in/e5NW5Xe
