Isaac
Stat Qty
Health 3
Damage 3.5(*1)
Tears 1
Shot Speed 1
Range 23.75
Speed 1
Luck 0
Starting Items
One regular bomb.
The D6 (once unlocked)
On Use: Any Treasure Room item will be rerolled into a different item.
(Defeat enemy Isaac in the Cathedral using ??? to unlock this item.)
Starting Effects
None
How to Unlock
Default Character
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Isaac's Head
Defeat Satan Mom's Knife
Defeat Isaac Isaac's Tears
Defeat The Chest D20
Defeat the Dark Room Missing Poster
Defeat Mom's Heart/ It Lives on Hard Lost Baby
Defeat Ultra Greed Lil' Chest
Defeat Hush Fart Baby
. Defeat Mega Satan Cry Baby
. Defeat Everything on Hard Buddy Baby
Biblical Reference
Child whom God asked his father Abraham to sacrifice.
Magdalene
Stat Qty
Health 4
Damage 3.5(*1)
Tears 1
Shot Speed 1
Range 23.75
Speed 0.85
Luck 1
Starting Items
Yum Heart
On Use: Heals one Red Heart.
Recharge: Four rooms.
Starting Effects
None
How to Unlock
Have 7 or more Red Heart containers at one time.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Isaac The Relic
Defeat Boss Rush Maggy's Bow
Defeat Satan Guardian Angel
Defeat The Chest Celtic Cross
Defeat the Dark Room Maggy's Faith
Defeat Mom's Heart/ It Lives on Hard Cute Baby
Defeat Ultra Greed Censer
. Defeat Hush Purity
. Defeat Mega Satan Red Baby
. Defeat Everything on Hard Colorful Baby
Biblical Reference
Mary Magdalene, a prostitue before meeting and befriending Jesus.
Cain
Stat Qty
Health 2
Damage 3.5(*1.2)
Tears 1
Shot Speed 1
Range 17.75
Speed 1.3
Luck 0
Starting Items
One regular key.
Starting Effects
Lucky Foot
Passive: Increases Luck
How to Unlock
Have 55 or more pennies at once.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Isaac Sack of Pennies
Defeat Boss Rush Cain's Other Eye
Defeat Satan Bomb Bag
Defeat The Chest Cain's Eye
Defeat the Dark Room Abel
Defeat Mom's Heart/ It Lives on Hard Glass Baby
Defeat Ultra Greed Evil Eye
. Defeat Hush D12
. Defeat Mega Satan Green Baby
. Defeat Everything on Hard Picky Baby
Biblical Reference
Son of Adam and Eve. Commited the first act of murder when he killed his brother Abel.
Judas
Stat Qty
Health 1
Damage 3.5(*1.35)
Tears 1
Shot Speed 1
Range 23.75
Speed 1
Luck 0
Starting Items
Three pennies.
Book of Belial
On Use: Increases damage dealt for the current room.
Recharge: Three rooms
Starting Effects
None
How to Unlock
Defeat Satan.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Judas' Shadow
Defeat Satan Judas' Tongue
Defeat Isaac Guillotine
Defeat the Chest The Left Hand
Defeat the Dark Room Curved Horn
Defeat Mom's Heart/ It Lives on Hard Shadow Baby
Defeat Ultra Greed My Shadow
. Defeat Hush Betrayal
. Defeat Mega Satan Brown Baby
. Defeat Everything on Hard Belial Baby
Biblical Reference
One of the 12 disciples. Betrayed Jesus in exchange for money.
Eve
Stat Qty
Health 2
Damage 3.5(*0.75)
Tears 1
Shot Speed 1
Range 23.75
Speed 1.23
Luck 0
Starting Items
None
Starting Effects
Dead Bird
Passive: When hit, a dead bird spawns and attacks enemies in the current room.
W'hore of Babylon
Passive: When at one heart of life, damage and speed is increased.
How to Unlock
Do not pick up any Hearts (Red, Spirit, Eternal, Demon) for two floors.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Eve's Mascara
Defeat Satan Razor Blade
Defeat Isaac Eve's Bird Foot
Defeat The Chest Sacrificial Dagger
Defeat the Dark Room Black Lipstick
Defeat Mom's Heart/ It Lives on Hard Crow Baby
. Defeat Ultra Greed Black Feather
. Defeat Hush Athame
. Defeat Mega Satan Lil' Baby
. Defeat Everything on Hard ♥♥♥♥♥ Baby
Biblical Reference
First woman. Took a bite from the forbidden fruit, comitting the first act of sin.
Samson
Stat Qty
Health 3
Damage 3.5(*1)
Tears 0.95
Shot Speed 1.31
Range 18.75
Speed 1.1
Luck 0
Starting Items
None
Starting Effects
Bloody Lust
Passive: Each time damage is taken, damage dealt is increased a small amount. Damage bonus resets each floor.
How to Unlock
Do not take damage for two floors.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Samson's Chains
Defeat Satan Blood Rights
Defeat Isaac Bloody Lust
Defeat The Chest Bloody Penny
Defeat the Dark Room Samson's Lock
Defeat Mom's Heart/ It Lives on Hard Fighting Baby
. Defeat Ultra Greed Lusty Blood
. Defeat Hush Blind Rage
. Defeat Mega Satan Rage Baby
. Defeat Everything on Hard Revenge Baby
Biblical Reference
Born by God to defeat the Philistines. After revealing his secret, lost his power and was subsequently captured and blinded.
Azazel
Stat Qty
Health -1
Damage 3.5(*1.5)
Tears -14
Shot Speed 1
Range 17.75
Speed 1.25
Luck 0
Starting Items
0 - The Fool
On Use: Teleports user to starting room on current floor.
Starting Effects
Special
Starts with three Demon Hearts as health. When a Demon Heart disappears, damage is dealt to all enemies in the room. Azazel can still obtain Red Heart Containers normally.
Special
Instead of tears, charges up and fires a short-range Brimstone beam that resembles a thick laser.
Flying
Can fly over rocks, holes, and poop. Ignores damage from floor spikes and pools of hazardous liquid. Can still be damaged by bombs, red poop, enemies, and projectiles.
How to Unlock
Make three deals with the Devil in one run.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush The Nail
Defeat Satan Daemon's Tail
Defeat Isaac The Satanic Bible
Defeat The Chest Abaddon
Defeat the Dark Room Demon Baby
Defeat Mom's Heart/ It Lives on Hard Wrapped Baby
Defeat Ultra Greed Unlocks Lilith
Defeat Hush Maw of the Void
. Defeat Mega Satan Black Baby
. Defeat Everything on Hard Sucky Baby
Biblical Reference
A scapegoat, or in some translations, the name of a fallen angel who helped further the corruption of Man preceeding the great flood.
Lazarus
Stat Qty
Health 3
Damage 3.5(*1)
Tears 1
Shot Speed 1
Range 17.75
Speed 1
Luck -1
Starting Items
A random pill.
Starting Effects
Special
Upon death, will revive once with one Red Heart container and the Anemic passive.
Anemic (after revive)
Passive:Range up.
Passive: When damage is taken, leave a trail of blood that damages enemies. Resets when leaving current room.
How to Unlock
Have four Spirit Hearts at once.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Missing No.
Defeat Satan Broken Ankh
Defeat Isaac Lazarus' Rags
Defeat the Dark Room Pandora's Box
Defeat the Chest Store Credit
Defeat Mom's Heart/ It Lives on Hard Begotten Baby
Defeat Ultra Greed Key Bum
Defeat Hush Empty Vessel
Defeat Mega Satan Long Baby
Defeat Everything on Hard Dripping Baby
Biblical Reference
Was ressurected by Jesus four days after dying.
Eden
Stat Qty
Health ?
Damage ?
Tears ?
Shot Speed ?
Range ?
Speed ?
Luck ?
Eden is neither male nor female.
Using Eden requires the use of a special token. Additional tokens are obtained each time Mom's Heart / It Lives is defeated.
Starting Items
Randomized, see below
Starting Effects
Special
Starts with...
Randomized Stats
Random hair style
1: coin, bomb, key, pill, or card
0-1: activated item
0-2: passive items
How to Unlock
Defeat The Womb chapter.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Undefined
Defeat Satan The Book of Secrets
Defeat Isaac A Blank Card
Defeat The Chest Mysterious Paper
Defeat the Dark Room Mystery Sack
Defeat Mom's Heart/ It Lives on Hard Glitch Baby
Defeat Ultra Greed GB Bug
. Defeat Hush Eden's Blessing
. Defeat Mega Satan Yellow Baby
. Defeat Everything on Hard Cracked Baby
Biblical Reference
None directly, although it's interesting to note that the place Adam and Eve orignally resided was the Garden of Eden.
???
Stat Qty
Health -1
Damage 3.5(*1.05)
Tears 1
Shot Speed 1
Range 23.75
Speed 1.1
Luck 0
Also known as the Blue Baby.
Starting Items
The Poop
On Use: Spawns a poop.
Recharge: One room.
Starting Effects
Special
Starts with three Soul Hearts. Cannot obtain Red Heart Containers. Any time health would be increased, ??? instead gains that many Soul Hearts.
How to Unlock
Defeat Mom's Heart ten times.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush ???'s Only Friend
Defeat The Chest Fate
Defeat Satan Forget Me Now
Defeat Isaac D6
Defeat the Dark Room ???'s Soul
Defeat Mom's Heart/ It Lives on Hard Dead Baby
. Defeat Ultra Greed Cracked Dice
. Defeat Hush Fate's Reward
. Defeat Mega Satan Blue Baby
. Defeat Everything on Hard Hive Baby
Biblical Reference
None. Often thought to refer to Edmund McMillen, original game creator, and some of his past work which depict a similar character.
The Lost
Stat Qty
Health 0
Damage 3.5(*1)
Tears 1
Shot Speed 1
Range 23.75
Speed 1
Luck 0
Dies if game is left mid-run.
Starting Items
One penny.
Starting Effects
Flying
Can fly over rocks, holes, and poop. Ignores damage from floor spikes and pools of hazardous liquid. Can still be damaged by bombs, red poop, enemies, and projectiles.
Special
Cannot pick up Hearts of any kind and cannot have health increased. Damage taken results in a death. Revive items function normally.
Note that as a side effect, all Devil Room items can be taken without cost.
How to Unlock
You must die as specific characters and by specific means. These four can be done in any order (in one play session) as long as there are NO other losses in between. Currently, seeds will work. The following order is recommended:
As Isaac, die by a Mulliboom's explosion in either the Basement or Cellar (Seed: JTMD EZPF, go down).
As Magdalene, die by your own bomb in either the Caves or Catacombs.
As Judas, die by Mom. Easiest way is to damage self to half a heart before entering then running to middle of room.
As Azazel, die by Satan during his second phase (after The Fallen, before the hooves) in Sheol.
Mulliboom:
Appears rarely. Slightly more common in Cellar. Setting difficulty to Hard adds a few more rooms with Mullibooms to the generation list, making them a bit more common to encounter.
You can use your own bombs to blow up doors to get through rooms with lots of enemies without killing them, saving some time.
Unlike other explosions, these deal only a half heart of damage.
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush D100
Defeat Satan The Mind
Defeat Isaac Isaac's Heart
Defeat The Chest The Body
Defeat the Dark Room The Soul
Defeat Everything on Hard Godhead
Defeat Mom's Heart/ It Lives on Hard -0- Baby
. Defeat Ultra Greed Zodiac
. Defeat Hush Sworn Protector
. Defeat Mega Satan White Baby
Biblical Reference
None directly. A lost soul, resembles the spirit that leaves the body of other characters upon death.
Lilith
Stat Qty
Health 1
Damage 3.5(*1)
Tears 0
Shot Speed 1
Range 23.75
Speed 1
Luck 0
Starting Items
Box of Friends
On Use: Duplicate's Isaac's familiars for the duration of the current room.
Recharge: Two rooms
Starting Effects
Special
Lilith is blindfolded and cannot fire tears.
Incubus
Passive: Summons a familiar that fires tears. Gains the same effects as Isaac's tears.
Special
Starts with two Demon Hearts as health. When a Demon Heart disappears, damage is dealt to all enemies in the room. Lilith can still obtain Red Heart Containers normally.
How to Unlock
Beat Greed Mode with Azazel
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Immaculate Conception
Defeat Satan Serpent's Kiss
Defeat Isaac Rune Bag
Defeat The Chest Cambion conception
Defeat the Dark Room Succubus
Defeat Mom's Heart/ It Lives on Hard Goat Head Baby
Defeat Ultra Greed Box of Friends
Defeat Hush Incubus
Defeat Mega Satan Big Baby
. Defeat Everything on Hard Dark Baby
Biblical Reference
In some texts, Lilith was Adam's first wife but was cast out of the Garden of Eden when she refused to listen to God, who later replaced her with Eve. Lilith is often referenced with demonic associations in bibical texts.
Keeper
.
Stat Qty
Health -1
Damage 3.5(*1.2)
Tears 1
Shot Speed 1
Range 23.75
Speed 0.85
Luck -2
Starting Items
One regular bomb.
One coin (after defeating the Hush with Keeper).
Wooden Nickel
On Use: 50% chance to drop a coin.
Recharge: One room
(Unlocked by defeating Isaac in the Cathedral)
Store Key
Trinket: May open shops without using a key.
(Unlocked by defeating Satan in Sheol)
Starting Effects
Special
Starts with two "coins" of health. Being damaged loses a health. Picking up a coin gains a health. Cannot exceed two health. HP Up items and effects will refresh Keeper's health to two.
Special
Heart pickups turn into Blue Flies.
Special
Triple Shot - shoots three tears per shot.
How to Unlock
Donate 1000 coins to the Greed Mode donation machine (causing it to explode).
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
--- Action Unlocked
Defeat Boss Rush Sticky Nickel
. Defeat Satan Store Key
. Defeat Isaac Wooden Nickel
. Defeat The Chest Deep Pockets
. Defeat the Dark Room Karma
. Defeat Mom's Heart/ It Lives on Hard Super Greed Baby
. Defeat Ultra Greed Rib of Greed
. Defeat Hush Keeper's Penny
. Defeat Mega Satan Noose Baby
. Defeat Everything on Hard Sale Baby
Biblical Reference
n/a
